Anastrazole is a prescription medication classified as an “aromatase inhibitor.” It was initially developed for use as an adjuvant treatment for hormone receptor positive breast cancer, as a way to reduce circulating estrogen and prevent tumor growth. Anastrazole is prescribed where appropriate in hormone replacement therapy to reduce estrogen levels and preserve testosterone.
What is aromatase?
Aromatase is an enzyme that converts testosterone into estrogen. Increased activity of aromatase can make it nearly impossible to achieve healthy testosterone levels, even in the presence of testosterone replacement. Aromatase leads to deficient testosterone levels with excessive estrogen (estradiol).
What causes increased aromatase activity?
Aromatase activity increases naturally with age. It is also stimulated by excess body fat, increased levels of insulin (as with pre-diabetes and insulin resistance), stress, alcohol consumption, and exposure to certain pesticides.
What are the symptoms of high estrogen levels in men?
Common symptoms related to elevated estradiol levels are:
The development of breast tissue (gynecomastia)
Weight gain, particularly abdominal
Elevated estrogen can also increase your risk of stroke, heart attack and prostate cancer.
Does anastrazole cause any side effects?
Most of the side effects experienced when taking this medication are related to the decline in estrogen, and the most common symptoms often mimic menopause. Once estrogen levels stabilize and return to a normal range, symptoms should subside. They may include:
How is anastrazole administered?
Anastrazole is taken via oral tablet. Your dose and frequency will be determined by our physician, based on your lab results and physical symptoms.